Publications - Published papers

Please find below publications of our group. Currently, we list 53 papers. Some of the publications are in collaboration with the group of Peter Stadler and are also listed in the publication list for his group. Access to published papers (access) is restricted to our local network and chosen collaborators.
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Evolution of the let-7 microRNA Family

Jana Hertel, Sebastian Bartschat, Axel Wintsche, Christian Otto, The Students of the Bioinformatics Computer Lab 2011, Peter F Stadler

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RNA Biology 9: 231-241 (2012)

Abstract


The increase of bodyplan complexity in early bilaterian evolution is intimately linked with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In bilateria it appears stably associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a complex system of developmental regulators. In this contribution we disentangle the evolutionary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths and deuterostomes. The foundation of a second let-7 locus in the common ancestor of vertebrates and urochordates predates the vertebrate-specific genome duplications, which then caused a rapid expansion of let-7 family.

Keywords


micro RNA, let-7, mir-100, mir-125, miRNA evolution